Gardenalla Vaginalis & Rickettesia

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Questions:

Q. Enumerate Salient Features of Gardenalla Vaginalis?

Q. How is Bacterial vaginosis Treated?

Q. Which Rickettisial Diseases present with a rash?

Q. Which Rickettisial diseases present without a rash?

Q. What is the treatment of Rickettisial infections?

Answers:

Q. Enumerate Salient Features of Gardenalla Vaginalis?

A pleomorphic, gram-variable rod that causes vaginosis presenting as a gray vaginal discharge with a fishy smell ; nonpainful.

Associated with sexual activity, but not an STD.

Bacterial vaginosis is characterized by overgrowth of certain bacteria in vagina.

Clue cells, (vaginal epithelial cells covered with bacteria), are visible under the microscope

Q. How is Bacterial vaginosis Treated?

Metronidazole

Q. Which Rickettisial Diseases present with a rash?

Rocky Mountain spotted fever

Rash typically starts at wrists and ankles and then spreads to trunk, palms, and soles. Rickettsiae are obligate intracellular organisms that need CoA and NAD+.

Typhus:

• Endemic (fleas) -R. typhi.

• Epidemic (human body louse) -R. prowazekii. Rash starts centrally and spreads out, sparing palms and soles.

Q. Which Rickettisial diseases present without a rash?

Ehrlichiosis (tick) -Ehrlichia. Monocytes with morula (berry-like inclusions) in cytoplasm.

Anaplasmosis (tick) -Anaplasma. Granulocytes with morula in cytoplasm.

Q fever (tick feces and cattle placenta release spores that are inhaled as aerosols)

Coxiella bumetii. No arthropod vector. Presents as pneumonia.

Q. What is the treatment of Rickettisial infections?

Doxycycline (oral)

 

 

 
 
 

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